What is a “Novel” Protein, and Why They’re Important


If your dog has never eaten any of these meats, they are considered “novel” proteins.


I want to talk about elimination diets again, and specifically about the concept of “novel” proteins.

Elimination diets are used to determine what foods agree with your dog, and they’re used a lot in dogs that have IBD. These diets are meant to determine what protein sources your dog can safely eat.

Many of our CIL dogs also have IBD. Dogs with IBD are sensitive to certain proteins (meats). It’s similar to an allergy. Just as with allergies, they become sensitive specifically *after* exposure to that protein. So, a dog that’s never had turkey can’t possibly be sensitive to it. That would make it a good option to try if your dog is having problems like this.

A protein source that your dog has never been exposed to is called a “novel” protein.

Sometimes the challenge for us is to find a food that is both low-fat and novel. If you mix up a bunch of different meats and feed them to your dog at once, none of those meats will be novel anymore. Your dog might now be sensitive to all of them.

This is why I’m always saying choose a low-fat protein and feed that, and only that, until you’re sure it isn’t helping. The idea is that you will still have options if your dog becomes sensitive to the food that agreed with him yesterday.

So please don’t feed this and that and the other thing, even if it all seems to agree with your dog. You’re limiting your options down the road when you do that, if you should ever need them.

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Repost: CIL – Care and Feeding

Another repost to bring good information to the top!


Today I’d like to talk about diets for dogs with Canine Intestinal Lymphangiectasia (CIL). Simply put, there are two common forms of this disease which have somewhat different, but overlapping, dietary requirements. These are:

  • Primary lymphangiectasia (lymphangiectasia by itself), and
  • Lymphangiectasia secondary to Inflammatory Bowel Disease (IBD).

“Secondary” here means that your dog has a disease (IBD) which is causing another disease (lymphangiectasia).  When a disease is “secondary,” it means that treating the first (primary) disease will often fix the secondary disease.  What this means is that, with lymphangiectasia that is secondary to IBD, treating the IBD is more important.

So, what you need to feed your dog will differ somewhat, depending upon which form your dog has.  And here’s the catch:  Even with all the testing you’ve done, and even with your vet’s best guess, YOU may not know which form your dog has.  In this case, how your dog reacts to food will provide important information about his dietary needs.

There are generally two items in the diet that may need to be strictly controlled (FAT and PROTEIN), and what you need to do will depend upon which form of the disease is present.  We’ll look at this separately, and then we’ll look at what typically happens in a case where the situation is unclear.


In primary lymphangiectasia, the big enemy is fat.  If you can control the amount of fat in the diet, you can (in some cases) control the disease.  Treatment is simple and straightforward and typically consists of anti-inflammatory drugs and an ultra low-fat diet.  The diet may also be high in protein.  With luck, treatment will resolve the disease as long as strict dietary adherence is maintained.


If lymphangiectasia is secondary to IBD, your path is not so clear.  IBD is usually caused by protein intolerance (a negative reaction to certain kinds of proteins), so it becomes important at this point to determine whether or not your dog is reacting negatively to proteins in the diet.  The protein source in most diets is some kind of meat, so this is where you will need to look.  It is still critically important to reduce dietary fat, especially early in treatment.

Steps to take:

  1. Eliminate commonly fed proteins (especially chicken)
  2. Feed a hypoallergenic prescription diet, OR
  3. Slowly, and one at a time, introduce LEAN proteins that your dog has never eaten (examples of lean meats are bison, venison, kangaroo, whitefish such as tilapia or cod, or turkey).
  4. Observe over 24 hours what changes, if any, are seen in your dog after exposure to these proteins.

There are commercial, prescription diets available which can be tried initially.

Low fat diets include:

  • Royal Canin Gastrointestinal Low Fat
  • Hills w/d® Canine Low Fat

Hypoallergenic diets include:

  • Purina HA hypoallergenic dog food
  • Royal Canin Hypoallergenic dog food
  • Hills z/d® Canine ULTRA Allergen-Free

Your vet may recommend one of these diets.  These diets can provide a good starting point, but may not provide you with the full answer.


This happens quite a lot.  What it usually means is that your dog has an additional protein sensitivity that hasn’t been diagnosed.  You will need to begin to conduct low-fat protein trials to try to find a protein source that agrees with your dog (see “steps to take,” above).


  • Anti-inflammatory drugs are frequently prescribed.  These are often steroids, like prednisone.
  • Metronidazole (flagyl) is an antibiotic with anti-inflammatory properties.
  • Tylan (tylosin) is also sometimes recommended, especially in cases where the intestinal disease is suspected to be complicated by Small Intestinal Bacterial Overgrowth (SIBO).

So far we’ve talked about dietary needs and prescription products.  Many owners of lymphie dogs have found these products to be inadequate, and have turned to homemade or “hybrid” diets (diets containing but not limited to commercial products).  We’ll talk about these in another post.

— Louie’s mom

*SPECIFIC proteins, and you may have to figure out which ones.